COSSAC consists of three groups from three universities:

The group based at the department of Engineering at the University of Oxford focuses on "next generation" technologies which can be used for clinical (and non-clinical) applications;
The clinical group at University College London Medical School based at the Royal Free NHS Trust focuses on application development, evaluation and deployment.
The research group at the School of Informatics at University of Edinburgh focuses on the formal foundations for intelligent systems in healthcare delivery.

The director of COSSAC is John Fox, Professor of Engineering Science at the University of Oxford. John's co-investigators are David Glasspool, Senior Research Fellow in the School of Informatics at the University of Edinburgh, and Vivek Patkar, CRUK Clinical Research Fellow, Department of Oncology,